In this article, I will describe the methodology of transdisciplinarity. My analysis will be divided in several parts what means “beyond disciplines”; the distinction between multidisciplinarity, interdisciplinarity, indisciplinarity, and transdisciplinarity; the definition of disciplinary boundaries; the axioms of the methodology of transdisciplinarity the notion of “levels of Reality; the logic of included middle; and the universal interdependence. I will conclude by asserting that we are at the threshold of a New Renaissance.Keywords complexity, included middle, knowledge, reality, transdisciplinarity