Active substances from marine actinomycetes and mainly from the genus Streptomyces have wide application for medical as antibaterial and anticancer among others. In this paper, the authors showed antibacterial and anticancer activity of marine actinomycete strain S. variabilis HP411, which isolated from sediments of the North coastal region of Vietnam. The strain HP411 was gray group, mature spore chains of HP411 showed an elongated and circular shape with 10 to 30 spores per chain, spore surface warty. This strain could grow rapidly on starch casein agar and other media with temperature at 25-35°C, pH optimum 7-8, and high salt containing 7-10 percent NaCl (w/v). Antimicrobial and anticancer activity were carried out against test microorganisms (resistant methicillin S. aureus and S. epidermidis - MRSA, MRSE- Escherichia coli (ATCC 25922), S. epidemidis (ATCC 12228) and yeast strain C. albicans (ATCC 10231). Further studies revealed that the crude extract of strain HP411 could obtain the anticancer activity for cancer cell line: MCF7 (breast adenocarcinoma cell line) and the IC50 value with 61.47 +/- 1.1 (ug/ml). The antibiotic horn the strain S. variabilis HP411 can further research as antimicrobial and anticancer agents in clinical trials.
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